| Expression pattern: |
UP |
| Associated gene: |
LASP1 |
| Associated microRNA: |
miR-3612 |
| Biological function: |
Promotes ESCC cell viability, colony formation, migration, invasion, glycolysis and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circ_0006948 acts as a ceRNA/miRNA sponge for miR-3612 to upregulate LASP1 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (other); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_0006948 expression was associated with shorter overall survival in ESCC patients and may be a potential biomarker or therapeutic target. |
| Description: |
circ_0006948 is up-regulated in ESCC tissues and cells, and high expression is associated with shorter overall survival. Functionally, circ_0006948 promotes ESCC proliferation, migration, invasion, glycolysis and in vivo tumor growth while inhibiting apoptosis. Mechanistically, it acts as a cytoplasmic ceRNA by sponging miR-3612 to increase LASP1 expression. |
| Confidence score: |
0.8174 |