| Expression pattern: |
DN |
| Associated gene: |
extracellular signal-regulated kinase signaling pathways |
| Associated microRNA: |
miRNA-21 |
| Biological function: |
inhibiting cell proliferation and promoting apoptosis; diagnostic biomarker for accurate gastric cancer screening |
| Molecular mechanism: |
sponging miRNA-21 and suppressing extracellular signal-regulated kinase signaling pathways |
| Biological pathway or process: |
ceRNA regulation (other); ERK (inhibits); proliferation (inhibits); apoptosis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
circRNA-HIAT1 combined with miRNA-21 improves gastric cancer screening accuracy; AUC and Youden's index reach 0.98 and 0.90 |
| Description: |
This study used fluorescent paper-based analytical devices to detect circRNA-HIAT1 in plasma for gastric cancer screening. circRNA-HIAT1 was significantly suppressed in GC patient plasma, and its combined detection with miRNA-21 markedly improved diagnostic performance. The paper also describes circRNA-HIAT1 as a GC-related circRNA that can sponge miRNA-21 and suppress ERK signaling based on prior biological context. |
| Confidence score: |
0.5261 |