| Expression pattern: |
UP |
| Associated gene: |
DNASE2 |
| Associated microRNA: |
miR-139-5p |
| Biological function: |
circ_0073228 acts as an oncogene in HCC cells, facilitating cell viability, proliferation, migration and invasion while inhibiting apoptosis. |
| Molecular mechanism: |
circ_0073228 functions as a competitive endogenous RNA by binding miR-139-5p and upregulating DNASE2 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_0073228 is an RPS23-derived circRNA upregulated in HCC cell lines. It promotes HCC cell growth, proliferation, migration and invasion and suppresses apoptosis by competitively binding miR-139-5p to increase DNASE2 expression. |
| Confidence score: |
0.741 |