| Expression pattern: |
DN |
| Associated gene: |
target mRNAs, down-regulated mRNAs |
| Associated microRNA: |
hsa-miR-6818-3p, hsa-miR-6821-5p, hsa-miR-1229-5p, hsa-miR-3119, hsa-miR-4743-3p |
| Biological function: |
Potentially participates in ankylosing spondylitis pathogenesis through a circRNA-miRNA-mRNA regulatory network related to immune regulation, bone remodeling and skeletal disorders. |
| Molecular mechanism: |
Predicted circRNA-miRNA-mRNA regulatory network; down-regulated circFCHSD2 may regulate mRNA expression through interacting miRNAs. |
| Biological pathway or process: |
JAK/STAT (other); Wnt/beta-catenin (other); immune regulation (other); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNA-seq; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
May serve as a candidate for diagnosis and targeted treatment of ankylosing spondylitis. |
| Description: |
hsa_circ_0005918 (circFCHSD2) was identified as a down-regulated circRNA shared between platelets and spinal ligament tissues of AS patients and was validated by qRT-PCR. The study predicts that circFCHSD2 participates in AS pathogenesis through a circRNA-miRNA-mRNA network involving immune regulation, JAK/STAT and Wnt-related processes, with potential diagnostic or therapeutic relevance. |
| Confidence score: |
0.4032 |