| Expression pattern: |
UP |
| Associated gene: |
WNT3A |
| Associated microRNA: |
miR‐195‐5p |
| Biological function: |
Promotes proliferation, migration, invasion, EMT, and metastasis; inhibits apoptosis in breast cancer cells. |
| Molecular mechanism: |
Acts as a miRNA sponge/competitive inhibitor of miR-195-5p to upregulate WNT3A, promoting EMT and metastasis. |
| Biological pathway or process: |
EMT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); Wnt/beta-catenin (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
M
|
| Validation methods: |
Microarray; RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
High circHSPA8 expression is associated with poor prognosis and lymphoid node metastasis; expression increased with higher pathological stages. |
| Description: |
circHSPA8 (hsa_circ_0024715), derived from HSPA8, is up-regulated in breast cancer tissues and cell lines and is associated with lymph node metastasis and poorer survival. Functionally, it promotes proliferation, invasion/migration, EMT, and lung metastasis by sponging miR-195-5p and thereby upregulating WNT3A (activating WNT/beta-catenin-related EMT programs). |
| Confidence score: |
0.8815 |