| Expression pattern: |
UP |
| Associated gene: |
Cyclin D1, Bcl-2, p21, Bax |
| Associated microRNA: |
miR-367-3p |
| Biological function: |
Knockdown of circBIRC6 inhibits ovarian cancer cell proliferation, induces apoptosis, increases cisplatin sensitivity, and impairs cisplatin resistance. |
| Molecular mechanism: |
circBIRC6 targets miR-367-3p; inhibition of circBIRC6 up-regulates miR-367-3p and modulates proliferation- and apoptosis-related proteins including Cyclin D1, Bcl-2, p21 and Bax. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); drug resistance (promotes); chemoresistance (promotes); cell cycle (promotes); mitochondrial function (other); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; MTT; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
May provide a potential target for ovarian cancer therapy. |
| Description: |
This study found that circBIRC6 is up-regulated in cisplatin-resistant ovarian cancer SKOV3/DDP cells. Silencing circBIRC6 inhibits proliferation, promotes apoptosis, and reduces cisplatin resistance, likely through up-regulation of miR-367-3p and regulation of Cyclin D1, Bcl-2, p21 and Bax. |
| Confidence score: |
0.5554 |