| Expression pattern: |
UN |
| Associated gene: |
HNRNPUL1 |
| Associated microRNA: |
- |
| Biological function: |
circMAN1A2 negatively regulates CDDP sensitivity and promotes CDDP resistance of ESCC cells; circMAN1A2 alone had no significant effect on ESCC cell proliferation or colony formation. |
| Molecular mechanism: |
HNRNPUL1 binds circMAN1A2 and regulates circMAN1A2 formation rather than stability, thereby inhibiting CDDP sensitivity in ESCC cells. |
| Biological pathway or process: |
drug resistance (promotes); chemoresistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; RNA-seq; RIP (RNA Immunoprecipitation); RNA Pull-Down; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circMAN1A2 expression was significantly correlated with HNRNPUL1 expression in fresh ESCC tissue samples; no direct prognostic or diagnostic value of circMAN1A2 was reported. |
| Description: |
This study identifies circMAN1A2 as a circRNA involved in cisplatin resistance in ESCC. HNRNPUL1 binds circMAN1A2 and regulates its formation; reduced circMAN1A2 sensitizes ESCC cells to cisplatin, whereas circMAN1A2 overexpression partially restores cisplatin resistance in vitro and in vivo. |
| Confidence score: |
0.8246 |