| Expression pattern: |
UP |
| Associated gene: |
ZEB2 |
| Associated microRNA: |
miR-625-5p |
| Biological function: |
promotes proliferation, migration and invasion and inhibits apoptosis of breast cancer cells; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circMMP11 sponges miR-625-5p to regulate ZEB2 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNA Pull-Down; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
High circMMP11 expression was associated with lymph node metastasis and TNM stage; proposed as a diagnostic marker and promising prognostic biomarker for BC |
| Description: |
circMMP11 is up-regulated in breast cancer tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-625-5p to de-repress ZEB2, thereby promoting proliferation, migration/invasion (with EMT marker changes) and inhibiting apoptosis, and its knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.705 |