| Expression pattern: |
UP |
| Associated gene: |
cyclin D1 / CCND1 |
| Associated microRNA: |
miR-302e |
| Biological function: |
Promotes NSCLC cell proliferation and cell cycle progression; acts as an oncogene and counteracts miR-302e-mediated tumor inhibition in vitro and in vivo. |
| Molecular mechanism: |
ceRNA mechanism: circ-CMPK1 sponges miR-302e, relieving repression of cyclin D1 (CCND1) and increasing cyclin D1 expression. |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Cell Cycle Assay; Western Blot; Clinical Sample Validation; Survival Analysis; In Vivo Animal Model |
| Clinical significance: |
High circ-CMPK1 expression is associated with poor prognosis and shorter survival time in NSCLC patients. |
| Description: |
circ-CMPK1 is up-regulated in NSCLC and promotes tumor cell proliferation and cell-cycle progression. Mechanistically, it acts as a ceRNA that sponges miR-302e, thereby increasing cyclin D1 (CCND1) expression and enhancing tumor growth, including in a xenograft model. |
| Confidence score: |
0.7353 |