circRNA basic information
circBase ID: hsa_circ_0087862
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent tissues
Cell lines:

SW620
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CCND1
Associated microRNA: miR-892b
Biological function: Promotes CCND1 expression by attenuating miR-892b-mediated translational inhibition (predicted regulatory role).
Molecular mechanism: ceRNA mechanism (circRNA binds miRNA to reduce translational inhibition of target gene).
Biological pathway or process:

ceRNA regulation (promotes); cell cycle (promotes); proliferation (promotes)
Detected method:
M
Validation methods:

Bioinformatics Analysis; Microarray
Clinical significance:

-
Description:

The study proposes a ceRNA axis where up-regulated has-circ-0087862 binds miR-892b and thereby relieves translational inhibition on CCND1, increasing CCND1 expression in CRC; this is based on bioinformatic network construction rather than direct experimental validation for this circRNA.
Confidence score:

0.1768
Other information
Title:

Bioinformatics analysis-based screening of circRNA gene with mainstream expression trend in colorectal cancer and construction of a coexpression regulatory network.

Journal: PloS one
Published: 2023
PubMed ID: 38064496
Study type:

bioinformatics study
Data availability: GSE126094; GSE21815; TCGA
Code availability: -