| Expression pattern: |
UP |
| Associated gene: |
YAP1 |
| Associated microRNA: |
miR-375 |
| Biological function: |
Promotes gastric cancer stem cell malignant phenotypes (proliferation/self-renewal, migration, invasion) and inhibits apoptosis; enhances tumorigenicity in vivo. |
| Molecular mechanism: |
Acts as a miR-375 sponge (ceRNA-like) to relieve miR-375-mediated repression of YAP1, promoting downstream malignant signaling (including Notch-related proteins). |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); EMT (promotes); Hippo/YAP (promotes); Notch (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); H&E Staining; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
In gastric cancer stem cells, circ_0051246 is overexpressed and promotes proliferation/self-renewal, migration and invasion while inhibiting apoptosis. Mechanistically, it sponges miR-375 to increase YAP1 expression (with associated Notch-related protein changes), enhancing tumorigenicity in a cell line-derived orthotopic xenograft model. |
| Confidence score: |
0.6978 |