circRNA basic information
circBase ID: -
Name: hsa_circ_FOXO3
Synonym: circFOXO3
Host Gene: FOXO3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 -
MONDO name: -
Disease details: human aging phenotypes
Disease DO ID:
 -
Disease MeSH ID:
 D000375
Disease NCIt ID:
 C16269
Disease ICD11 ID:
 -
Disease OMIM ID:
 502000
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: negatively associated with parental longevity score; differentially expressed in senescent human primary cells
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

circRNA-seq; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Lower circFOXO3 expression was associated with higher parental longevity score.
Description:

circFOXO3 was associated with human parental longevity score and showed dysregulated expression in senescent primary human cell types, implicating it in aging-related phenotypes and cellular senescence.
Confidence score:

0.5466
Other information
Title:

circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan.

Journal: GeroScience
Published: 2020
PubMed ID: 31811527
Study type:

combined biological and clinical study
Data availability: Online Resource 1; Online Resource 3; Online Resource 4
Code availability: -