| Expression pattern: |
UP |
| Associated gene: |
Lin28A, Lin28B |
| Associated microRNA: |
- |
| Biological function: |
Promotes proliferation, migration, invasion, sphere formation/CSC features and chemoresistance; inhibits apoptosis; promotes EMT in colorectal cancer cells. |
| Molecular mechanism: |
circ_0067557 directly binds Lin28A and Lin28B (RBP interaction) and upregulates their expression, mediating CAF-derived exosome-driven malignant phenotypes and chemoresistance. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); apoptosis (inhibits); chemoresistance (promotes); stemness (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; divergent primers PCR; RIP (RNA Immunoprecipitation); RNA Pull-Down; Western Blot; Transfection; CCK8; EdU Staining; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Colony Formation Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); TUNEL; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_0067557 is enriched/upregulated in CAF-derived exosomes and drives colorectal cancer malignant behaviors and chemoresistance. Mechanistically, circ_0067557 directly binds the RBPs Lin28A and Lin28B, increasing their expression; circ_0067557 silencing reverses CAF-exosome-induced proliferation, EMT/CSC traits, invasion/migration and drug resistance and increases apoptosis, including in xenografts. |
| Confidence score: |
0.8124 |