| Expression pattern: |
UP |
| Associated gene: |
MET, FGFR1 |
| Associated microRNA: |
miR-26b-5p, miR-198 |
| Biological function: |
circ_0079558 promotes proliferation, migration and invasion, inhibits apoptosis, and supports xenograft tumor growth in papillary thyroid carcinoma. |
| Molecular mechanism: |
circ_0079558 functions as a miRNA sponge for miR-26b-5p to enhance MET expression and activate MET/AKT signaling; it also interacts with miR-198 and affects FGFR1-mediated proliferation. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); PI3K/AKT (promotes); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
High circ_0079558 expression was associated with large tumor size, advanced TNM stage and N stage, and circ_0079558/miR-26b-5p/MET axis might be a promising diagnostic target for PTC management. |
| Description: |
circ_0079558 is up-regulated in papillary thyroid carcinoma tissues and cell lines and acts as an oncogenic circRNA. It promotes PTC cell proliferation, migration, invasion and xenograft tumor growth while inhibiting apoptosis, mainly by sponging miR-26b-5p to increase MET expression and activate MET/AKT signaling; a miR-198/FGFR1-related proliferative axis was also implicated. |
| Confidence score: |
0.7052 |