| Expression pattern: |
UP |
| Associated gene: |
TEP1 |
| Associated microRNA: |
miR-16-5p |
| Biological function: |
hsa_circ_0005721 promotes proliferation, migration and invasion of osteosarcoma cells and inhibits apoptosis. |
| Molecular mechanism: |
hsa_circ_0005721 acts as a ceRNA to upregulate the linear transcript TEP1 by competitively binding miR-16-5p. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Actinomycin D / DRB Stability Assay; RNase R Treatment; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
hsa_circ_0005721 is up-regulated in osteosarcoma tissues and cell lines. It promotes osteosarcoma cell proliferation, migration and invasion while suppressing apoptosis. Mechanistically, it functions as a ceRNA that binds miR-16-5p to upregulate the linear transcript TEP1. |
| Confidence score: |
0.7581 |