circRNA basic information
circBase ID: hsa_circ_0005721
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr14:20871535-20874559:-
Genomic location(hg38): chr14:20403376-20406400:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma / OS
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

cancer tissues; adjacent normal tissues; plasma
Cell lines:

hFOB; 143B; U-2OS; HOS; Saos-2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: hsa_circ_0005721 acts as an oncogene in osteosarcoma and promotes osteosarcoma cell proliferation; knockdown suppresses proliferative ability.
Molecular mechanism: The exact molecular mechanism was not clarified; knockdown of hsa_circ_0005721 decreased PCNA level and suppressed proliferation.
Biological pathway or process:

proliferation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; Colony Formation Assay; EdU Staining; Survival Analysis; ROC Analysis
Clinical significance:

High level of hsa_circ_0005721 predicted poor prognosis in osteosarcoma patients; hsa_circ_0005721 has diagnostic potential and may serve as a promising diagnostic marker for osteosarcoma.
Description:

hsa_circ_0005721 is up-regulated in osteosarcoma tissues, osteosarcoma cell lines, and patient plasma. High expression is associated with worse overall survival, larger tumors and advanced stage, while knockdown suppresses proliferation in U-2OS and HOS cells. Plasma hsa_circ_0005721 shows diagnostic potential for distinguishing osteosarcoma patients from healthy controls and benign bone tumor patients.
Confidence score:

0.6419
Other information
Title:

A potential diagnostic marker for osteosarcoma: hsa_circ_0005721.

Journal: Journal of B.U.ON. : official journal of the Balkan Union of Oncology
Published: 2021
PubMed ID: 34565022
Study type:

combined biological and clinical study
Data availability: -
Code availability: -