| Expression pattern: |
UP |
| Associated gene: |
VIM |
| Associated microRNA: |
- |
| Biological function: |
Circ-VIM is upregulated in AML, serves as a diagnostic and prognostic biomarker, is associated with higher WBC count and shorter OS/LFS, and may promote AML occurrence and progression by regulating VIM. |
| Molecular mechanism: |
Circ-VIM expression is positively correlated with its parental gene VIM expression; the authors suggest Circ-VIM might promote AML occurrence and progress by regulating VIM, but no direct mechanistic assay was performed. |
| Biological pathway or process: |
other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Cohort Study; Survival Analysis |
| Clinical significance: |
Circ-VIM may serve as a diagnostic biomarker for distinguishing AML patients from controls and as an independent poor prognostic factor for OS and LFS. |
| Description: |
Circ-VIM is significantly upregulated in AML BMNC samples and its high expression distinguishes AML patients from healthy controls. High Circ-VIM expression is associated with worse OS and LFS and is an independent poor prognostic factor. The study also reports a positive correlation between Circ-VIM and its host gene VIM, suggesting a possible role in AML progression through VIM regulation. |
| Confidence score: |
0.4992 |