| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-4482-3p, hsa-miR-146a-3p |
| Biological function: |
Potential serum diagnostic biomarker for NSCLC; serum levels could discriminate NSCLC from healthy, pneumonia, and benign lung tumor conditions, but were not correlated with assessed NSCLC clinical parameters. |
| Molecular mechanism: |
Predicted circRNA-miRNA ceRNA-related regulatory network; the underlying mechanism was not experimentally elucidated. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0003317 discriminated benign lung tumor from NSCLC with AUC 0.659; the combination hsa_circ_0008167 + hsa_circ_0003317 had AUC 0.847, but hsa_circ_0003317 was not correlated with assessed clinical parameters. |
| Description: |
hsa_circ_0003317 was up-regulated in serum from NSCLC patients and showed diagnostic value for distinguishing NSCLC from benign lung tumor, especially when combined with hsa_circ_0008167 or the selected miRNAs. Unlike hsa_circ_0008167, hsa_circ_0003317 was not significantly associated with the assessed clinicopathological parameters in NSCLC. |
| Confidence score: |
0.459 |