circRNA basic information
circBase ID: hsa_circ_0000673
Name: hsa_circ_RSL1D1
Synonym: -
Host Gene: RSL1D1
Genomic location(hg19): chr16:11940357-11940700:-
Genomic location(hg38): chr16:11846500-11846843:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; plasma; adjacent non-cancerous tissues
Cell lines:

AGS; BGC823; MGC803; MKN28; MKN45; HGC-27; SGC7901; HEK-293 T; GES-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: RUNX3, p21, Bim, E-cadherin
Associated microRNA: miR-532-5p
Biological function: Inhibits gastric cancer cell proliferation, colony formation, invasion, and tumor growth in vivo; acts as a tumor suppressor.
Molecular mechanism: Acts as a sponge for miR-532-5p, leading to up-regulation of RUNX3 and downstream effectors (p21, Bim, E-cadherin).
Biological pathway or process:

proliferation (inhibits); invasion (inhibits); metastasis (other); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; MTT; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model
Clinical significance:

hsa_circ_0000673 expression was negatively correlated with GC stage, and plasma hsa_circ_0000673 level was significantly down-regulated in patients with GC, suggesting diagnostic biomarker potential.
Description:

hsa_circ_0000673 is down-regulated in gastric cancer tissues, cell lines, and plasma, and its lower expression correlates with higher GC stage. Functionally, it suppresses GC cell proliferation, colony formation, invasion, and xenograft tumor growth by sponging miR-532-5p and thereby increasing RUNX3 (and downstream p21, Bim, E-cadherin) expression.
Confidence score:

0.6829
Other information
Title:

Hsa_circ_0000673 is down-regulated in gastric cancer and inhibits the proliferation and invasion of tumor cells by targetting miR-532-5p.

Journal: Bioscience reports
Published: 2018
PubMed ID: 30061181
Study type:

combined biological and clinical study
Data availability: GSE83521; GSE78092
Code availability: -