circRNA basic information
circBase ID: -
Name: hsa_circ_CRIM1
Synonym: circCRIM1
Host Gene: CRIM1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma / OS
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

OS tissues; adjoining normal tissues; adjacent non-tumor tissues
Cell lines:

U2OS; SAOS-2; MG-63; 143B; hFOB1.19
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-513
Biological function: circCRIM1 inhibits osteosarcoma cell proliferation, migration, invasion, metastasis, and progression, and acts as a tumor inhibitor.
Molecular mechanism: circCRIM1 functions as a competing endogenous RNA by directly binding and sponging miR-513, thereby suppressing osteosarcoma cell proliferation, migration, and invasion.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; MTT; EdU Staining; Transwell Assay; Luciferase Reporter Assay; Survival Analysis; Bioinformatics Analysis
Clinical significance:

Depressed circCRIM1 expression was correlated with lymph node metastasis, advanced FIGO stage, and low overall survival of OS patients; circCRIM1 may serve as a potential therapeutic target for OS treatment.
Description:

circCRIM1 is down-regulated in osteosarcoma tissues and cell lines, and low expression is associated with advanced FIGO stage, lymph node metastasis, and worse overall survival. Functionally, circCRIM1 acts as a tumor suppressor that inhibits OS cell proliferation, migration, and invasion. Mechanistically, it functions as a ceRNA sponge for miR-513 in the circCRIM1/miR-513 pathway.
Confidence score:

0.7078
Other information
Title:

The circular RNA circCRIM1 inhibits osteosarcoma progression through sponging miR-513.

Journal: Mammalian genome : official journal of the International Mammalian Genome Society
Published: 2021
PubMed ID: 34480205
Study type:

combined biological and clinical study
Data availability: -
Code availability: -