circRNA basic information
circBase ID: hsa_circ_0000592
Name: hsa_circ_MGA
Synonym: circ_0000592
Host Gene: MGA
Genomic location(hg19): chr15:41988272-41991357:+
Genomic location(hg38): chr15:41696074-41699159:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC specimens; adjacent normal specimens; tumor tissues; healthy tissues; xenograft tumor tissues
Cell lines:

AGS; SNU1; HGC27; MKN45; N87; GES-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: ANXA4
Associated microRNA: miR-1179
Biological function: Circ_0000592 promotes gastric cancer cell proliferation, migration, invasion, glycolysis and xenograft tumor growth; its knockdown suppresses these malignant behaviors.
Molecular mechanism: ceRNA mechanism: circ_0000592 sponges miR-1179 to elevate ANXA4 expression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; EdU Staining; Transwell Assay; Western Blot; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry)
Clinical significance:

Circ_0000592 high expression was correlated with advanced TNM stage and may be a diagnostic/prognostic biomarker and therapeutic target for gastric cancer.
Description:

Circ_0000592 is up-regulated in gastric cancer tissues and cell lines and correlates with advanced TNM stage. It promotes GC progression by sponging miR-1179 and increasing ANXA4 expression, thereby enhancing proliferation, migration, invasion, glycolysis and tumor growth in vivo.
Confidence score:

0.7537
Other information
Title:

Circular RNA circ_0000592 elevates ANXA4 expression via sponging miR-1179 to facilitate tumor progression in gastric cancer.

Journal: Anti-cancer drugs
Published: 2022
PubMed ID: 34459457
Study type:

combined biological and clinical study
Data availability: The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -