| Expression pattern: |
UP |
| Associated gene: |
FLT-1, ALKBH5, METTL3, YTHDF2 |
| Associated microRNA: |
miR-378a-3p |
| Biological function: |
Promotes HCC cell proliferation, invasion and migration; promotes angiogenesis; promotes tumor growth and lung metastasis in vivo. |
| Molecular mechanism: |
m6A modification regulation by ALKBH5 and METTL3; ceRNA sponging miR-378a-3p to upregulate FLT-1 (FLT1). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); angiogenesis (promotes); ceRNA regulation (promotes); other pathway/process (other) |
| Detected method: |
Q
H
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; ISH (In Situ Hybridization); FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; MeRIP / MeRIP-seq; Transfection; CCK8; EdU Staining; Colony Formation Assay; Cell Cycle Assay; Transwell Assay; Tube Formation Assay; In Vivo Animal Model; H&E Staining; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ-CCT3 expression is associated with poor prognosis and is an independent risk factor for overall survival in HCC patients; potential biomarker. |
| Description: |
circ-CCT3 (hsa_circ_0004680), derived from CCT3, is up-regulated in HCC and predicts poor prognosis. It promotes HCC proliferation, migration/invasion, angiogenesis and in vivo tumor growth/metastasis mainly by sponging miR-378a-3p to increase FLT1, and its level is regulated via m6A-related factors including ALKBH5 and METTL3. |
| Confidence score: |
0.8869 |