| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
May serve a role in BC tumorigenesis as a transcriptional regulator (based on ceRNA network and enrichment analyses). |
| Molecular mechanism: |
ceRNA mechanism (predicted miRNA sponging) with downstream target mRNAs inferred by bioinformatics; PI3K-AKT pathway enrichment among predicted targets; ORF predicted (possible translation). |
| Biological pathway or process: |
PI3K/AKT (other); stemness (other); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; divergent primers PCR; Sanger Sequencing; Clinical Sample Validation |
| Clinical significance: |
Potential diagnostic biomarkers for patients with BC (suggested). |
| Description: |
hsa_circ_0043278 (circTADA2A) is down-regulated in breast cancer tissues and cell lines. The paper predicts it functions within a circRNA-miRNA-mRNA ceRNA network, with enrichment implicating PI3K-AKT signaling and stem-cell pluripotency regulation among associated pathways; an ORF is predicted suggesting possible translation. |
| Confidence score: |
0.5541 |