| Expression pattern: |
UP |
| Associated gene: |
MAP2 |
| Associated microRNA: |
- |
| Biological function: |
circ_001680 promotes proliferative and metastatic abilities in gastric carcinoma cells; knockdown suppresses proliferation, migration and invasion. |
| Molecular mechanism: |
circ_001680 aggravates gastric carcinoma malignant development by negatively interacting with and targeting MAP2. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Western Blot; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High level of circ_001680 predicted high incidences of lymphatic and distant metastasis, and poor prognosis in GC patients. |
| Description: |
circ_001680 is up-regulated in gastric carcinoma tissues and cell lines, and high expression is associated with lymphatic metastasis, distant metastasis and poor survival. Functionally, circ_001680 promotes GC cell proliferation, migration and invasion, at least partly through a negative circ_001680-MAP2 regulatory axis. |
| Confidence score: |
0.7365 |