| Expression pattern: |
UP |
| Associated gene: |
AKT2 |
| Associated microRNA: |
miR-506-3p |
| Biological function: |
Promotes colorectal cancer cell proliferation, migration, and invasion; circPTK2 knockdown induces apoptosis and inhibits EMT-related changes. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-506-3p, relieving miR-506-3p-mediated repression of AKT2 and thereby increasing AKT2 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot |
| Clinical significance: |
- |
| Description: |
circPTK2 is up-regulated in colorectal cancer cell lines and promotes malignant phenotypes (proliferation, migration, invasion). Mechanistically, it sponges miR-506-3p to relieve repression of AKT2, forming a circPTK2/miR-506-3p/AKT2 ceRNA axis that drives CRC progression. |
| Confidence score: |
0.5301 |