| Expression pattern: |
UP |
| Associated gene: |
COL1A1 |
| Associated microRNA: |
hsa-miR-634, hsa-miR-129-5p, hsa-miR-145-5p, hsa-miR-21-3p, hsa-miR-29a-3p, hsa-miR-501-5p |
| Biological function: |
Potential biomarker for gastric cancer diagnosis and treatment. |
| Molecular mechanism: |
May act as a miRNA sponge and may regulate parental gene transcription. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis; RT-qPCR; divergent primers PCR; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
AUC=0.94 in distinguishing GC and normal patients (ROC analysis). |
| Description: |
circCOL1A1 is up-regulated in gastric cancer tissues versus adjacent normal tissues and was validated by RT-qPCR. Bioinformatic analyses suggest it may sponge GC-related miRNAs (including hsa-miR-21-3p and hsa-miR-145-5p) and it shows diagnostic potential by ROC analysis (AUC 0.94). |
| Confidence score: |
0.5963 |