circRNA basic information
circBase ID: hsa_circ_0023990
Name: hsa_circ_NOX4
Synonym: -
Host Gene: NOX4
Genomic location(hg19): chr11:89165951-89185063:-
Genomic location(hg38): chr11:89432783-89451895:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002108
MONDO name: thyroid cancer
Disease details: thyroid cancer / TC
Disease DO ID:
 1781
Disease MeSH ID:
 -
Disease NCIt ID:
 C7510
Disease ICD11 ID:
 447433352
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

normal thyroid tissues; papillary TC tissues; poorly differentiated or undifferentiated thyroid anaplastic carcinoma tissues; tumor tissues
Cell lines:

Nthy-ori 3-1; TPC1; K1; CAL-62; 8505C; FRO; 293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: FOXM1
Associated microRNA: miR-485-5p
Biological function: Promotes dedifferentiated thyroid cancer cell proliferation, cell-cycle progression, glycolysis, and tumor growth in vivo.
Molecular mechanism: hsa_circ_0023990 functions as a miRNA sponge for miR-485-5p, thereby upregulating FOXM1 expression and promoting proliferation and glycolysis.
Biological pathway or process:

proliferation (promotes); cell cycle (promotes); glycolysis (promotes); ceRNA regulation (promotes); other pathway/process (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; EdU Staining; Cell Cycle Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining
Clinical significance:

hsa_circ_0023990 might be a potential therapeutic target for dedifferentiated thyroid cancer treatment.
Description:

hsa_circ_0023990 is upregulated in thyroid cancer, especially dedifferentiated thyroid cancer tissues and cell lines. It promotes proliferation, cell-cycle progression, glycolysis, and xenograft tumor growth by sponging miR-485-5p and increasing FOXM1 expression. The study suggests hsa_circ_0023990 as a potential therapeutic target for dedifferentiated thyroid cancer.
Confidence score:

0.7375
Other information
Title:

Hsa_circ_0023990 Promotes Tumor Growth and Glycolysis in Dedifferentiated TC via Targeting miR-485-5p/FOXM1 Axis.

Journal: Endocrinology
Published: 2021
PubMed ID: 34414414
Study type:

combined biological and clinical study
Data availability: All data generated or analyzed during this study are included in this article; available from the corresponding author on reasonable request
Code availability: -