circRNA basic information
circBase ID: hsa_circ_0110498
Name: hsa_circ_MAGI3
Synonym: circ_0110498
Host Gene: MAGI3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; adjacent healthy specimens; tumor tissues
Cell lines:

A549; H1299; 16HBE; A549/DDP; H1299/DDP
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: RBBP4, AGO2
Associated microRNA: miR-1287-5p
Biological function: Promotes cisplatin (DDP) resistance, proliferation, metastasis (migration/invasion) and glycolysis, and inhibits apoptosis in NSCLC.
Molecular mechanism: Acts as a miRNA sponge (ceRNA) for miR-1287-5p to upregulate RBBP4, thereby promoting DDP resistance.
Biological pathway or process:

ceRNA regulation (promotes); chemoresistance (promotes); glycolysis (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry)
Clinical significance:

-
Description:

circ_0110498 is up-regulated in NSCLC, especially in cisplatin (DDP)-resistant tissues/cells, and promotes DDP resistance, proliferation, migration/invasion, and glycolysis while suppressing apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-1287-5p to derepress RBBP4, and circ_0110498 knockdown increases DDP sensitivity in vitro and in a xenograft model.
Confidence score:

0.8037
Other information
Title:

Circ_0110498 facilitates the cisplatin resistance of non-small cell lung cancer by mediating the miR-1287-5p/RBBP4 axis.

Journal: Thoracic cancer
Published: 2023
PubMed ID: 36691322
Study type:

combined biological and clinical study
Data availability: -
Code availability: -