| Expression pattern: |
UP |
| Associated gene: |
EGFR, RAF1, Erk, Ki67, PCNA |
| Associated microRNA: |
miR-7 |
| Biological function: |
promotes aggressive oncogenic phenotype (proliferation, migration, invasion) and reduces apoptosis; neutralizes tumor-suppressive effects of miR-7; promotes tumor growth in xenografts |
| Molecular mechanism: |
Acts as a ceRNA/miR-7 sponge, relieving miR-7-mediated repression and activating EGFR/RAF1/MAPK signaling. |
| Biological pathway or process: |
MAPK (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Transfection; MTT; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
High ciRS-7 expression correlates with advanced stage/metastasis and predicts poor overall survival; independent risk factor for overall survival. |
| Description: |
ciRS-7 is up-regulated in colorectal cancer and functions as an oncogenic circRNA. It sponges miR-7, relieving repression of EGFR and RAF1 and promoting EGFR/RAF1/MAPK signaling, which enhances malignant phenotypes and is associated with poor patient survival. |
| Confidence score: |
0.7528 |