| Expression pattern: |
UP |
| Associated gene: |
CDC25A |
| Associated microRNA: |
miR-519-3p |
| Biological function: |
Promotes radioresistance, proliferation, migration, invasion, EMT and tumor growth of radio-resistant ESCC cells; silencing enhances radiosensitivity under radiation. |
| Molecular mechanism: |
hsa_circ_0014879 functions as a ceRNA by sponging miR-519-3p, thereby upregulating CDC25A and regulating ESCC radiosensitivity. |
| Biological pathway or process: |
radioresistance (promotes); proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0014879 is associated with ESCC radiotherapy response and may provide a promising target for improving ESCC survival rate. |
| Description: |
hsa_circ_0014879 is upregulated in radio-resistant ESCC tissues and cells. It promotes radioresistance and malignant phenotypes including proliferation, migration, invasion and EMT, while its knockdown enhances radiosensitivity. Mechanistically, hsa_circ_0014879 sponges miR-519-3p to upregulate CDC25A in the miR-519-3p/CDC25A axis. |
| Confidence score: |
0.6536 |