| Expression pattern: |
UP |
| Associated gene: |
HIF-1alpha, N-cadherin |
| Associated microRNA: |
miR-640 |
| Biological function: |
promotes migration of HCC cells |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-640, promoting HIF-1alpha expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); migration (promotes); HIF-1 signaling (promotes) |
| Detected method: |
Q
H
M
|
| Validation methods: |
Microarray; RT-qPCR; FISH / smFISH; Sanger Sequencing; Actinomycin D / DRB Stability Assay; Luciferase Reporter Assay; Transfection; Wound Healing Assay; Western Blot; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
High hsa-circ-0046600 expression was associated with tumour size, TNM stage and pathological vascular invasion; proposed as a biomarker for HCC diagnosis and disease progression. |
| Description: |
hsa-circ-0046600 is up-regulated in HCC tissues/cell lines and promotes HCC cell migration. It mainly localizes to the cytoplasm and functions as a miR-640 sponge to increase HIF-1alpha (and migration-related N-cadherin) expression, supporting a hsa-circ-0046600/miR-640/HIF-1alpha axis. |
| Confidence score: |
0.7791 |