| Expression pattern: |
UP |
| Associated gene: |
CPEB1, c-myc, beta-catenin |
| Associated microRNA: |
miR-377-3p |
| Biological function: |
promotes osteosarcoma cell proliferation, migration, invasion and tumor growth; inhibits apoptosis |
| Molecular mechanism: |
circ_0003732 sponges miR-377-3p to upregulate CPEB1 and activate Wnt/beta-catenin signaling pathway |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model |
| Clinical significance: |
may provide a promising therapeutic strategy for osteosarcoma treatment |
| Description: |
circ_0003732 is up-regulated in osteosarcoma tissues and cells and functions as a tumor-promoting circRNA. It promotes proliferation, migration, invasion and in vivo tumor growth while inhibiting apoptosis, mainly by sponging miR-377-3p to increase CPEB1 expression and activate Wnt/beta-catenin signaling. |
| Confidence score: |
0.786 |