| Expression pattern: |
DN |
| Associated gene: |
MYC |
| Associated microRNA: |
hsa-miR-30e-5p, hsa-miR-647, hsa-miR-92a-1-5p, hsa-miR-660-3p, hsa-miR-626 |
| Biological function: |
May play a role in hepatocellular carcinoma carcinogenesis and metastasis; potential diagnostic biomarker for HCC. |
| Molecular mechanism: |
Predicted ceRNA mechanism via hsa_circ_0004018-miR-30e-5p/miR-626-MYC axes (bioinformatics-based). |
| Biological pathway or process: |
ceRNA regulation (other); metastasis (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Lower expression of hsa_circ_0004018 was correlated with serum AFP level, tumor diameters, differentiation, BCLC stage and TNM stage; diagnostic value AUC=0.848 with sensitivity 0.716 and specificity 0.815. |
| Description: |
hsa_circ_0004018 is significantly down-regulated in HCC tissues and HCC cell lines and shows stage-specific decrease from chronic hepatitis to cirrhosis to HCC. The study predicts a ceRNA axis hsa_circ_0004018-miR-30e-5p/miR-626-MYC that may contribute to HCC carcinogenesis/metastasis and supports its diagnostic potential (AUC 0.848). |
| Confidence score: |
0.6556 |