| Expression pattern: |
UP |
| Associated gene: |
SMAD5, PI3K/AKT signaling pathway, Ago2 |
| Associated microRNA: |
miR-338-3p |
| Biological function: |
circ_0008450 promotes proliferation, colony formation, cell cycle progression, migration, invasion, tumor growth and cisplatin resistance, and inhibits apoptosis in CDDP-resistant NPC cells. |
| Molecular mechanism: |
circ_0008450 acts as a ceRNA by directly binding miR-338-3p, thereby mediating SMAD5 expression and modulating PI3K/AKT signaling in CDDP-resistant NPC cells. |
| Biological pathway or process: |
PI3K/AKT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes); drug resistance (promotes); chemoresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
Up-regulated circ_0008450 was correlated with NPC CDDP resistance and may provide potential targets for improving treatment of chemoresistant NPC. |
| Description: |
circ_0008450 is up-regulated in CDDP-resistant nasopharyngeal carcinoma tissues and cells. It promotes malignant phenotypes and cisplatin resistance by sponging miR-338-3p to regulate SMAD5 expression and activate PI3K/AKT signaling. Silencing circ_0008450 suppresses proliferation, migration, invasion and tumor growth while enhancing apoptosis and CDDP sensitivity. |
| Confidence score: |
0.7052 |