| Expression pattern: |
UP |
| Associated gene: |
SOX4, Ago2 |
| Associated microRNA: |
miR-646 |
| Biological function: |
Promotes DDP resistance, cell proliferation, colony formation, migration, invasion and cell cycle progression, and inhibits apoptosis in DDP-resistant NSCLC cells; circ-RNF121 knockdown improves DDP sensitivity in vitro and in vivo. |
| Molecular mechanism: |
circ-RNF121 functions as a ceRNA/sponge for miR-646, thereby upregulating SOX4 expression and enhancing DDP resistance in NSCLC cells. |
| Biological pathway or process: |
chemoresistance (promotes); drug resistance (promotes); proliferation (promotes); migration (promotes); invasion (promotes); cell cycle (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circ-RNF121 is upregulated in chemo-resistant NSCLC patient tissues and may be a promising therapeutic target for NSCLC treatment. |
| Description: |
circ-RNF121 is upregulated in NSCLC tissues, especially chemo-resistant NSCLC tissues, and in DDP-resistant NSCLC cell lines. It promotes cisplatin resistance and malignant phenotypes by sponging miR-646 to increase SOX4 expression; silencing circ-RNF121 enhances DDP sensitivity in vitro and in a xenograft model. |
| Confidence score: |
0.7053 |