| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-29b-2-5p, hsa-miR-199a-3p |
| Biological function: |
Associated with bortezomib tolerance/drug resistance and poor prognosis in multiple myeloma; suggested as a diagnostic and prognostic biomarker. |
| Molecular mechanism: |
Predicted circRNA-miRNA-mRNA interaction network; circRNA acts as a miRNA sponge (e.g., hsa-miR-29b-2-5p; hsa-miR-199a-3p). |
| Biological pathway or process: |
ceRNA regulation (other); drug resistance (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis |
| Clinical significance: |
May be used as a diagnostic marker for MM (AUC 0.907); upregulation correlated with poor prognosis (PFS). |
| Description: |
hsa_circ_0007841 is significantly up-regulated in multiple myeloma bone marrow samples and MM/drug-resistant cell lines. High expression is associated with bortezomib resistance and poorer progression-free survival, and it shows diagnostic potential (ROC AUC ~0.91). Mechanistically, it is proposed to act via a predicted circRNA-miRNA-mRNA network, including sponging hsa-miR-29b-2-5p and hsa-miR-199a-3p. |
| Confidence score: |
0.5534 |