circRNA basic information
circBase ID: hsa_circ_0004771
Name: hsa_circ_NRIP1
Synonym: circNRIP1
Host Gene: NRIP1
Genomic location(hg19): chr21:16386664-16415895:-
Genomic location(hg38): chr21:15014343-15043574:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent normal tissues; normal mammary tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker for breast cancer; significantly elevated in ER-negative and TNBC subgroups.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

divergent primers PCR; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

circNRIP1 showed excellent diagnostic potential for BC (AUC 0.98; sensitivity 0.92; specificity 0.97) and was described as the ideal diagnostic biomarker among the candidates.
Description:

circNRIP1 (hsa_circ_0004771) is significantly up-regulated in breast cancer tumor tissues and is elevated in ER-negative and TNBC subgroups. It shows the best diagnostic performance among tested circRNAs by ROC analysis.
Confidence score:

0.6238
Other information
Title:

Upregulation of CircCSPP1, CircNRIP1, and CircSMAD2 in Breast Cancer and Their Potential as Diagnostic Biomarkers.

Journal: Iranian biomedical journal
Published: 2025
PubMed ID: 40629030
Study type:

clinical study
Data availability: GSE101124
Code availability: -