| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Plasma hsa_circ_0007750 serves as part of a diagnostic circRNA panel for HBV-related HCC, Small-HCC, AFP-negative HCC and AFP-negative Small-HCC; it is secreted by HCC cells into plasma and is higher in HCC plasma and HCC tissues. |
| Molecular mechanism: |
No molecular mechanism was functionally defined; the study supports that HCC cells secrete this circRNA into plasma and that its plasma expression correlates with HCC tissue expression. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Microarray; Clinical Sample Validation; In Vivo Animal Model; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0007750 was included in a plasma CircPanel that performed better than AFP in diagnosing HCC and Small-HCC and also identified AFP-negative HCC and AFP-negative Small-HCC effectively. |
| Description: |
hsa_circ_0007750 is up-regulated in plasma from HBV-related HCC patients and in HCC tissues compared with adjacent noncancerous liver tissues. It is secreted by HCC cells into plasma and was incorporated into a three-circRNA diagnostic panel that outperformed AFP for detecting HCC, Small-HCC, AFP-negative HCC and AFP-negative Small-HCC. |
| Confidence score: |
0.7352 |