| Expression pattern: |
DN |
| Associated gene: |
RBM10 |
| Associated microRNA: |
- |
| Biological function: |
Oncogene-like in vitro: knockdown decreases colony formation and cell viability; can rescue RBM10-loss tumorigenic phenotype in cells, but no significant in vivo effect reported. |
| Molecular mechanism: |
RBM10 directly binds flanking intronic regions; position-dependent binding where upstream (5' flanking site) binding inhibits circularization (circSMARCA5). |
| Biological pathway or process: |
proliferation (inhibits); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; CLIP; Transfection; Colony Formation Assay; CCK8; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Reduced in LUAD tumoral samples in CPTAC cohort, but authors suggest limited/ context-dependent clinical relevance in LUAD. |
| Description: |
circSMARCA5 is an RBM10-regulated circRNA with direct RBM10 binding at its flanking regions and position-dependent inhibition of circularization. In LUAD cells, circSMARCA5 knockdown reduces growth-related phenotypes, but patient data show decreased tumor expression and the authors suggest its clinical relevance may be limited or context-dependent. |
| Confidence score: |
0.8116 |