circRNA basic information
circBase ID: -
Name: hsa_circ_FOXO3
Synonym: -
Host Gene: FOXO3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004986
MONDO name: urinary bladder carcinoma
Disease details: bladder cancer
Disease DO ID:
 4007
Disease MeSH ID:
 -
Disease NCIt ID:
 C4912
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

bladder cancer tissues; adjacent normal bladder tissue; murine bladder tumors; murine bladder tissue
Cell lines:

T24; UM-UC-3; J82; SV-HUC-1
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-191-5p
Biological function: promotes apoptosis; reduces cell viability
Molecular mechanism: miR-191-5p directly targets the 3ʹ-UTR of circ-Foxo3 and suppresses its expression and pro-apoptotic effect
Biological pathway or process:

apoptosis (promotes); proliferation (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; Western Blot; Annexin V/PI Flow Cytometry; CCK8; Luciferase Reporter Assay; In Vivo Animal Model; TUNEL; H&E Staining; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

circ-Foxo3 could be a potential therapeutic target for bladder cancer.
Description:

circ-Foxo3 is down-regulated in bladder cancer tissues and cell lines. Its overexpression promotes apoptosis and decreases viability of bladder cancer cells, and miR-191-5p directly binds the circ-Foxo3 3ʹ-UTR to suppress circ-Foxo3 expression and its pro-apoptotic effect.
Confidence score:

0.6542
Other information
Title:

Circular RNA circ-Foxo3 induced cell apoptosis in urothelial carcinoma via interaction with miR-191-5p.

Journal: OncoTargets and therapy
Published: 2019
PubMed ID: 31802888
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Code availability: -