circRNA basic information
circBase ID: hsa_circ_0141633
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum; GC tissue; paracancerous tissue; normal gastric mucosa epithelial tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Serves as a potential serum biomarker for diagnosis and evaluation of gastric cancer; high serum expression is associated with malignant clinicopathological characteristics and poor prognosis.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis
Clinical significance:

Serum has_circ_0141633 showed diagnostic value for gastric cancer with AUC 0.835, sensitivity 84.5%, and specificity 93.6%; high expression was associated with tumor diameter, differentiation, lymph node metastasis, TNM stage, and poor prognosis.
Description:

This clinical study found that has_circ_0141633 is up-regulated in both serum and tissues of gastric cancer patients. Serum has_circ_0141633 showed diagnostic potential for GC and correlated positively with tissue levels, while high expression was associated with malignant clinicopathological features and poorer survival. No molecular mechanism or regulatory axis was experimentally investigated.
Confidence score:

0.4992
Other information
Title:

Circulating circRNA Has_Circ_0141633 Serves as a Potential Biomarker for Gastric Cancer.

Journal: Clinical laboratory
Published: 2020
PubMed ID: 32902223
Study type:

clinical study
Data availability: -
Code availability: -