| Expression pattern: |
UP |
| Associated gene: |
PDK4, Ago2, ERBB2 mRNA, PCNA, MMP9, cleaved caspase 3 |
| Associated microRNA: |
miR-136-5p |
| Biological function: |
circ-ERBB2 promotes TNBC cell proliferation, migration, invasion, Warburg effect and in vivo tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circ-ERBB2 functions as a ceRNA by sponging miR-136-5p to upregulate PDK4 expression, thereby enhancing the Warburg effect and TNBC malignancy. |
| Biological pathway or process: |
glycolysis (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other); other pathway/process (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; RNA-seq; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; Colony Formation Assay; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ-ERBB2 expression is associated with TNM stage, lymph node metastasis and poor overall survival, and circ-ERBB2 may serve as a prognostic indicator/biomarker for TNBC. |
| Description: |
circ-ERBB2 is up-regulated in TNBC tissues and cells and high expression predicts poor overall survival. Functionally, circ-ERBB2 promotes glycolytic Warburg metabolism, proliferation, migration, invasion and tumor growth while suppressing apoptosis. Mechanistically, cytoplasmic circ-ERBB2 acts as a ceRNA sponge for miR-136-5p to increase PDK4 expression. |
| Confidence score: |
0.8769 |