circRNA basic information
circBase ID: hsa_circ_0000662
Name: hsa_circ_AXIN1
Synonym: -
Host Gene: AXIN1
Genomic location(hg19): chr16:398402-398484:-
Genomic location(hg38): chr16:348402-348484:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0013680
MONDO name: cognitive impairment with or without cerebellar ataxia
Disease details: white matter hyperintensity
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 614306
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cell (PBMC); peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: AXIN1
Associated microRNA: hsa-miR-194
Biological function: May participate in WMH occurrence by contributing to white matter damage and subsequent cognitive impairment.
Molecular mechanism: Predicted ceRNA mechanism: down-regulated hsa_circ_0000662 may sponge hsa-miR-194, regulate AXIN1 expression, and affect the Wnt signaling pathway.
Biological pathway or process:

Wnt/beta-catenin (other); ceRNA regulation (other); other pathway/process (promotes)
Detected method:
M
Validation methods:

Microarray; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0000662 was down-regulated in PBMCs from patients with WMH with or without cognitive impairment compared with controls. The study predicted that it may regulate the hsa-miR-194/AXIN1 axis and contribute to white matter injury through Wnt signaling.
Confidence score:

0.348
Other information
Title:

Differential expression of circular RNA in patients with white matter hyperintensity and cognitive impairment.

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Published: 2021
PubMed ID: 34911837
Study type:

combined clinical and bioinformatics study
Data availability: -
Code availability: -