| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-197-5p, hsa-miR-6871-5p, hsa-miR-6751-5p, hsa-miR-6803-5p, hsa-miR-194-3p |
| Biological function: |
Potential plasma biomarker; down-regulated in AD (not significantly changed in MCI). |
| Molecular mechanism: |
Predicted circRNA-miRNA-mRNA regulatory network and enrichment analyses; no experimental validation of specific interactions reported. |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
ROC analysis showed good diagnostic accuracy for distinguishing AD from healthy controls (AUC 0.829). |
| Description: |
hsa_circRNA_102049 (TADA2A locus) is decreased in plasma of AD patients compared with healthy controls and does not show AD-like upregulation in MCI. The study supports its diagnostic potential via ROC analysis and suggests a predicted circRNA-miRNA-mRNA regulatory role based on bioinformatic analyses. |
| Confidence score: |
0.5963 |