circRNA basic information
circBase ID: hsa_circ_0137008
Name: -
Synonym: circ_0137008
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; adjacent normal tissues; xenograft tumors
Cell lines:

FHC; HT29; HCT116; HCT8; LOVO; SW480; SW620
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-338-5p
Biological function: Inhibits CRC cell proliferation, migration, invasion, EMT, and suppresses tumor growth in vivo.
Molecular mechanism: Acts as a miR-338-5p sponge (ceRNA-like interaction), negatively regulating miR-338-5p and attenuating miR-338-5p-mediated malignant phenotypes.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); EMT (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Western Blot; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; Nuclear-Cytoplasmic Fractionation; Transfection; In Vivo Animal Model; Clinical Sample Validation
Clinical significance:

hsa_circ_0137008 may be a potential biomarker for diagnosis and prediction of prognosis of patients with CRC.
Description:

hsa_circ_0137008 is down-regulated in colorectal cancer tissues and cell lines. Its overexpression suppresses CRC cell proliferation, migration, invasion and EMT and inhibits xenograft tumor growth, mainly by sponging miR-338-5p and antagonizing miR-338-5p-driven malignant effects.
Confidence score:

0.7099
Other information
Title:

Hsa_circ_0137008 suppresses the malignant phenotype in colorectal cancer by acting as a microRNA-338-5p sponge.

Journal: Cancer cell international
Published: 2020
PubMed ID: 32158357
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -