circRNA basic information
circBase ID: hsa_circ_0002138
Name: hsa_circ_USP3
Synonym: circUSP3
Host Gene: USP3
Genomic location(hg19): chr15:63824845-63855207:+
Genomic location(hg38): chr15:63532646-63563008:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

leukocytes; whole blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: linear USP3
Associated microRNA: -
Biological function: circUSP3 is upregulated in CRC leukocytes, but its diagnostic performance was not statistically significant by ROC analysis; it showed high specificity and PPV but poor sensitivity and NPV.
Molecular mechanism: No disease mechanism was experimentally tested; the study measured leukocyte expression, correlation with the linear USP3 isoform, and diagnostic performance.
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

The circular USP3 assay did not show significant diagnostic potential by ROC analysis, although it exhibited high specificity and PPV.
Description:

circUSP3 is upregulated in leukocytes from patients with colorectal cancer and correlates positively with linear USP3 expression in the CRC group. Unlike circMETTL3, its ROC analysis was not statistically significant, so its value as a CRC biomarker remains limited in this study.
Confidence score:

0.4187
Other information
Title:

Upregulation of circular and linear METTL3 and USP3 in colorectal cancer.

Journal: Oncology letters
Published: 2021
PubMed ID: 34345300
Study type:

clinical study
Data availability: available from the corresponding author on reasonable request
Code availability: -