| Expression pattern: |
UP |
| Associated gene: |
PARP14, PKM2, PCNA, Bcl-2, Bax, Ki67 |
| Associated microRNA: |
miR-506-3p |
| Biological function: |
Facilitates HCC development; promotes glycolysis metabolism, cell vitality, cell proliferation, colony formation, invasion, and xenograft tumor growth; inhibits apoptosis. |
| Molecular mechanism: |
hsa_circ_0016788 acts as a miR-506-3p sponge to increase PARP14 expression, thereby regulating HCC progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); glycolysis (promotes); proliferation (promotes); invasion (promotes); apoptosis (inhibits); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
Potential targeted therapy for HCC treatment. |
| Description: |
hsa_circ_0016788 is up-regulated in HCC tissues and HCC cell lines. It promotes HCC progression by sponging miR-506-3p and increasing PARP14 expression, thereby enhancing glycolysis, proliferation, colony formation, invasion, and tumor growth while suppressing apoptosis. The study suggests that hsa_circ_0016788 may represent a potential therapeutic target for HCC. |
| Confidence score: |
0.8299 |