| Expression pattern: |
UP |
| Associated gene: |
CCNB2, AGO2, HIPK3, Bcl-2, Bax |
| Associated microRNA: |
miR-582-3p |
| Biological function: |
Promotes malignant HCC phenotypes, including proliferation, migration and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
hsa_circ_0000285 acts as a miR-582-3p sponge to increase CCNB2 expression, thereby promoting HCC progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); apoptosis (inhibits); cell cycle (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0000285 is suggested as a prospective target for HCC treatment and a promising target for HCC diagnosis and treatment. |
| Description: |
hsa_circ_0000285 is up-regulated in HCC tumor tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration and tumor growth while inhibiting apoptosis, mainly by sponging miR-582-3p to up-regulate CCNB2. The study suggests hsa_circ_0000285 as a potential therapeutic and diagnostic target for HCC. |
| Confidence score: |
0.7795 |