circRNA basic information
circBase ID: -
Name: hsa_circ_SMARCA5
Synonym: CircSMARCA5 / circular RNA SMARCA5
Host Gene: SMARCA5
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

CircSMARCA5 showed diagnostic value for early HCC (AUC 0.91 at cut-off 4.55; specificity 83.8%; sensitivity 91.7%) and may be a more sensitive predictor than AFP.
Description:

CircSMARCA5 is significantly down-regulated in plasma from HCC patients compared with HCV cirrhotic patients and controls. Plasma CircSMARCA5 shows strong diagnostic performance for early HCC and may outperform AFP in sensitivity.
Confidence score:

0.4187
Other information
Title:

Evaluation of Circular RNA SMARCA5 as a Novel Biomarker for Hepatocellular Carcinoma.

Journal: Asian Pacific journal of cancer prevention : APJCP
Published: 2024
PubMed ID: 38680002
Study type:

clinical study
Data availability: -
Code availability: -