circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF91
Synonym: novel_circ_0010155
Host Gene: ZNF91
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 1060198
MONDO name: ischemic stroke
Disease details: large artery atherosclerotic stroke / LAA stroke
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; plasma exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Candidate biomarker (differentially expressed) selected for immune/inflammatory relevance.
Molecular mechanism: Not specified (described as derived from ZNF91 and involved in transcriptional regulation).
Biological pathway or process:

immune regulation (other); inflammation (other); other pathway/process (other)
Detected method:
Q
S
Validation methods:

circRNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Differentially expressed between LAA and NC; however not statistically different between LAA and SAO in large sample replication.
Description:

Novel_circ_0010155 (derived from ZNF91) is down-regulated in circulating exosomes from LAA stroke patients versus controls and was selected for RT-qPCR validation based on immune/inflammatory enrichment. In large replication it did not distinguish LAA from SAO, suggesting limited specificity for LAA subtype among stroke groups.
Confidence score:

0.4685
Other information
Title:

Circulating Exosomal circRNAs Contribute to Potential Diagnostic Value of Large Artery Atherosclerotic Stroke.

Journal: Frontiers in immunology
Published: 2021
PubMed ID: 35095932
Study type:

combined biological and clinical study
Data availability: GSE190869; GSE173719
Code availability: -