| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
promotes esophageal cancer cell proliferation, migration, and invasion; inhibits apoptosis |
| Molecular mechanism: |
gene silencing of circFNDC3B inhibited proliferation, increased apoptosis, and reduced migration and invasion; specific downstream molecular mechanism was not determined |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Transfection; Annexin V/PI Flow Cytometry; Transwell Assay; H&E Staining |
| Clinical significance: |
circFNDC3B might be developed as a novel esophageal marker and may provide a basis for application of circular RNAs in cancer diagnosis and treatment |
| Description: |
circFNDC3B, a circRNA generated from FNDC3B exons, is up-regulated in esophageal cancer tissues. Functional silencing experiments in ECA109 and KYSE150 cells indicate that circFNDC3B promotes proliferation, migration, and invasion while suppressing apoptosis, supporting a pro-progression role in esophageal cancer. |
| Confidence score: |
0.7039 |