| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Potential diagnostic biomarker to differentiate CRC and IBD from healthy controls; associated with increased serum levels in CRC, UC and CD. |
| Molecular mechanism: |
Not experimentally defined in this study; discussed as potentially related to FUNDC1/mitophagy and mitochondrial dynamics in cancer and inflammation. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
Serum CircFUNDC1 is significantly higher in CRC, UC and CD vs controls and shows diagnostic performance by ROC analysis for differentiating CRC or IBD from controls and CRC from UC/CD. |
| Description: |
Serum CircFUNDC1 is up-regulated in CRC as well as UC and CD compared with healthy controls. It shows good diagnostic performance by ROC analysis for distinguishing CRC/IBD from controls and CRC from UC/CD, supporting its use as a non-invasive biomarker (especially for CRC). |
| Confidence score: |
0.4187 |