| Expression pattern: |
DN |
| Associated gene: |
EIF4E3 |
| Associated microRNA: |
miR-592 |
| Biological function: |
inhibits proliferation and metastasis (migration and invasion) of gastric cancer cells |
| Molecular mechanism: |
acts as a ceRNA (miRNA sponge) for miR-592 to relieve repression of EIF4E3 |
| Biological pathway or process: |
proliferation (inhibits); metastasis (inhibits); migration (inhibits); invasion (inhibits); EMT (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
circVDAC3 is a valuable prognostic biomarker of GC |
| Description: |
circVDAC3 (hsa_circ_0005927), derived from VDAC3, is down-regulated in gastric cancer tissues/cell lines and suppresses GC cell proliferation and metastasis in vitro and in xenograft models. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-592, thereby relieving miR-592-mediated repression of EIF4E3 to exert tumor-suppressive effects. |
| Confidence score: |
0.84 |