| Expression pattern: |
DN |
| Associated gene: |
SFRP1 |
| Associated microRNA: |
miR-940 |
| Biological function: |
circ_0046264 suppresses osteosarcoma progression and inhibits proliferation, migration and invasion of osteosarcoma cells. |
| Molecular mechanism: |
circ_0046264 acts as a ceRNA by adsorbing miR-940 and indirectly modulating SFRP1 expression via the miR-940/SFRP1 axis. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Transfection; EdU Staining; Transwell Assay; Luciferase Reporter Assay; Western Blot |
| Clinical significance: |
Low expression of circ_0046264 was associated with larger tumor diameter and positive Ki67 expression in patients with osteosarcoma. |
| Description: |
circ_0046264 is down-regulated in osteosarcoma tissues and cell lines and functions as a tumor suppressor. It mainly localizes in the cytoplasm, inhibits osteosarcoma cell proliferation, migration and invasion, and acts through a ceRNA mechanism involving miR-940 and SFRP1. Low circ_0046264 expression is associated with larger tumor diameter and positive or higher Ki67 expression. |
| Confidence score: |
0.7489 |