| Expression pattern: |
UP |
| Associated gene: |
FGF13, Ago2 |
| Associated microRNA: |
miR-1225-5p |
| Biological function: |
promotes proliferation, migration and invasion and inhibits apoptosis in colorectal cancer cells; promotes tumor growth in vivo |
| Molecular mechanism: |
circ-PNN acts as a ceRNA sponge for miR-1225-5p to upregulate FGF13 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; CCK8; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
potential therapeutic target for CRC |
| Description: |
Exosomal circ-PNN is up-regulated in plasma exosomes from colorectal cancer patients and promotes CRC cell proliferation, migration/invasion while inhibiting apoptosis, as well as enhancing xenograft tumor growth. Mechanistically, circ-PNN functions as a ceRNA sponge for miR-1225-5p to increase FGF13 expression, forming a circ-PNN/miR-1225-5p/FGF13 regulatory axis. |
| Confidence score: |
0.8299 |