circRNA basic information
circBase ID: -
Name: -
Synonym: CiRS-7
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker for CRC
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

Diagnostic biomarker in serum (ROC AUC 0.79)
Description:

CiRS-7 is elevated in CRC patient serum and shows diagnostic value for CRC detection (AUC 0.79), but it was not correlated with lymph node metastasis or TNM stage in this study.
Confidence score:

0.4187
Other information
Title:

Exosomal circ_0084043 derived from colorectal cancer-associated fibroblasts promotes in vitro endothelial cell angiogenesis by regulating the miR-140-3p/HIF-1alpha/VEGF signaling axis.

Journal: Heliyon
Published: 2024
PubMed ID: 38828320
Study type:

clinical study
Data availability: Data supporting the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -